A consensus database of the accessible human surfaceome.
Roughly 10–20% of human proteins reach the cell surface, yet over 65% of approved drugs target these molecules — accessibility on the extracellular face of the plasma membrane lets a drug act without crossing into the cell. Five public databases (UniProt, GO Cellular Component, the Human Protein Atlas, the Cell Surface Protein Atlas, and SURFY) each catalog the surfaceome, but with different definitions and methods, so their calls disagree more often than they agree.
This atlas reconciles them. An LLM triage agent scores every protein-coding human gene against the union of the five sources; a deep-dive agent then assembles the evidence behind each strong candidate — surface-localization methods, antibody validation, isoform topology, accessibility caveats — into per-gene records. Open accession, evidence-cited, agent-readable.
Curated shortlists over the deep-dive cohort. Canonical is the strictest tier, Likely is broader, Cell-state induced and Cell-type restricted are sub-buckets of Likely.
Applies only to genes with a deep-dive record. Non-deep-dive rows auto-exclude because the predicate reads fields the catalog row doesn't carry. The count badge on each chip is the population that survives the predicate alone — refine further with the existing search and facet chips below.
Strictest tier — direct evidence (single or multi-method), high/moderate confidence, surface-dominant or mixed, low / moderate / unclear state-dependence, high/moderate surface accessibility, high/moderate evidence density. The high-confidence surface shortlist.
Applies only to genes with a deep-dive record. Non-deep-dive rows auto-exclude because the predicate reads fields the catalog row doesn't carry.
Broader shortlist — adds supportive-but-indirect evidence, mostly-intracellular surface fractions (e.g. SRC via lysosomal exocytosis, HMGB1 via DAMP release), and high / unclear / null state-dependence.
Applies only to genes with a deep-dive record. Non-deep-dive rows auto-exclude because the predicate reads fields the catalog row doesn't carry.
Subset of Likely where surface presentation is induced by cell state (oncogenic transformation, stress, infection, immune activation). HSPA5, SRC, CD63, HMGB1, C3 land here.
Applies only to genes with a deep-dive record. Non-deep-dive rows auto-exclude because the predicate reads fields the catalog row doesn't carry.
Subset of Likely with constitutive surface in specific cell types only (KLK2 in prostate, etc.). Different cell types — not same cell across states.
Applies only to genes with a deep-dive record. Non-deep-dive rows auto-exclude because the predicate reads fields the catalog row doesn't carry.
19,324 genesTSV is verdicts + reason codes only. Free-text reasoning per run is on GET /v1/triage/{SYMBOL}; the full deep-dive SurfaceomeRecord is on GET /v1/genes/{SYMBOL}.